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- Rehana Akter
- Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA
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- Ping Cao
- Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA
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- Harris Noor
- Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA
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- Zachary Ridgway
- Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA
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- Ling-Hsien Tu
- Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA
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- Hui Wang
- Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA
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- Amy G. Wong
- Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA
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- Xiaoxue Zhang
- Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA
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- Andisheh Abedini
- Diabetes Research Program, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
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- Ann Marie Schmidt
- Diabetes Research Program, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
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- Daniel P. Raleigh
- Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA
書誌事項
- 公開日
- 2016
- 権利情報
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- http://creativecommons.org/licenses/by/3.0/
- DOI
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- 10.1155/2016/2798269
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose homeostasis but aggregates to form islet amyloid in type-2 diabetes. Islet amyloid formation contributes to<jats:italic>β</jats:italic>-cell dysfunction and death in the disease and to the failure of islet transplants. Recent work suggests a role for IAPP aggregation in cardiovascular complications of type-2 diabetes and hints at a possible role in type-1 diabetes. The mechanisms of IAPP amyloid formation<jats:italic>in vivo</jats:italic>or<jats:italic>in vitro</jats:italic>are not understood and the mechanisms of IAPP induced<jats:italic>β</jats:italic>-cell death are not fully defined. Activation of the inflammasome, defects in autophagy, ER stress, generation of reactive oxygen species, membrane disruption, and receptor mediated mechanisms have all been proposed to play a role. Open questions in the field include the relative importance of the various mechanisms of<jats:italic>β</jats:italic>-cell death, the relevance of reductionist biophysical studies to the situation<jats:italic>in vivo</jats:italic>, the molecular mechanism of amyloid formation<jats:italic>in vitro</jats:italic>and<jats:italic>in vivo</jats:italic>, the factors which trigger amyloid formation in type-2 diabetes, the potential role of IAPP in type-1 diabetes, the development of clinically relevant inhibitors of islet amyloidosis toxicity, and the design of soluble, bioactive variants of IAPP for use as adjuncts to insulin therapy.</jats:p>
収録刊行物
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- Journal of Diabetes Research
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Journal of Diabetes Research 2016 1-18, 2016
Wiley
