3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain
-
- Norihiro Shibuya
- National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Kiyose, Tokyo, Japan.
-
- Makiko Tanaka
- National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Kiyose, Tokyo, Japan.
-
- Mikiharu Yoshida
- National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Kiyose, Tokyo, Japan.
-
- Yuki Ogasawara
- Meiji Pharmaceutical University
-
- Tadayasu Togawa
- Meiji Pharmaceutical University
-
- Kazuyuki Ishii
- Meiji Pharmaceutical University
-
- Hideo Kimura
- National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Kiyose, Tokyo, Japan.
書誌事項
- 公開日
- 2009-04
- 権利情報
-
- https://journals.sagepub.com/page/policies/text-and-data-mining-license
- DOI
-
- 10.1089/ars.2008.2253
- 公開者
- SAGE Publications
この論文をさがす
説明
<jats:p> Hydrogen sulfide (H <jats:sub>2</jats:sub> S) is a synaptic modulator as well as a neuroprotectant. Currently, pyridoxal-5′-phosphate (PLP)-dependent cystathionine β-synthase (CBS) is thought to be the major H <jats:sub>2</jats:sub> S-producing enzyme in the brain. We recently found that brain homogenates of CBS-knockout mice, even in the absence of PLP, produce H <jats:sub>2</jats:sub> S at levels similar to those of wild-type mice, suggesting the presence of another H <jats:sub>2</jats:sub> S-producing enzyme. Here we show that 3-mercaptopyruvate sulfurtransferase (3MST) in combination with cysteine aminotransferase (CAT) produces H <jats:sub>2</jats:sub> S from cysteine. In addition, 3MST is localized to neurons, and the levels of bound sulfane sulfur, the precursor of H <jats:sub>2</jats:sub> S, are greatly increased in the cells expressing 3MST and CAT but not increased in cells expressing functionally defective mutant enzymes. These data present a new perspective on H <jats:sub>2</jats:sub> S production and storage in the brain. <jats:italic toggle="yes">Antioxid. Redox Signal.</jats:italic> 11, 703–714. </jats:p>
収録刊行物
-
- Antioxidants & Redox Signaling
-
Antioxidants & Redox Signaling 11 (4), 703-714, 2009-04
SAGE Publications