Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis
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- Chiara Fenoglio
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
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- Elisa Ridolfi
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
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- Claudia Cantoni
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
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- Milena De Riz
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
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- Rossana Bonsi
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
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- Maria Serpente
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
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- Chiara Villa
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
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- Anna M Pietroboni
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
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- Robert T Naismith
- Department of Neurology, Washington University School of Medicine, USA
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- Enrique Alvarez
- Department of Neurology, Washington University School of Medicine, USA
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- Becky J Parks
- Department of Neurology, Washington University School of Medicine, USA
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- Nereo Bresolin
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
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- Anne H Cross
- Department of Neurology, Washington University School of Medicine, USA
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- Laura M Piccio
- Department of Neurology, Washington University School of Medicine, USA
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- Daniela Galimberti
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
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- Elio Scarpini
- Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
説明
<jats:p> Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients ( p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS ( p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers. </jats:p>
収録刊行物
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- Multiple Sclerosis Journal
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Multiple Sclerosis Journal 19 (14), 1938-1942, 2013-11-25
SAGE Publications