Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis

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  • Chiara Fenoglio
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
  • Elisa Ridolfi
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
  • Claudia Cantoni
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
  • Milena De Riz
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
  • Rossana Bonsi
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
  • Maria Serpente
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
  • Chiara Villa
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
  • Anna M Pietroboni
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
  • Robert T Naismith
    Department of Neurology, Washington University School of Medicine, USA
  • Enrique Alvarez
    Department of Neurology, Washington University School of Medicine, USA
  • Becky J Parks
    Department of Neurology, Washington University School of Medicine, USA
  • Nereo Bresolin
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
  • Anne H Cross
    Department of Neurology, Washington University School of Medicine, USA
  • Laura M Piccio
    Department of Neurology, Washington University School of Medicine, USA
  • Daniela Galimberti
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
  • Elio Scarpini
    Department of Pathophysiology and Transplantation “Dino Ferrari” Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy

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<jats:p> Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients ( p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS ( p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers. </jats:p>

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