HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain

  • Edward C. Emery
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
  • Gareth T. Young
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
  • Esther M. Berrocoso
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
  • Lubin Chen
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
  • Peter A. McNaughton
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.

Description

<jats:p>Action potential firing, initiated by HCN2 ion channels, is the basic mechanism underlying neuropathic pain.</jats:p>

Journal

  • Science

    Science 333 (6048), 1462-1466, 2011-09-09

    American Association for the Advancement of Science (AAAS)

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