The interplay between vitamin D and viral infections

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  • Majid Teymoori‐Rad
    Department of Virology, School of Public Health Tehran University of Medical Sciences Tehran Iran
  • Fazel Shokri
    Department of Immunology, School of Public Health Tehran University of Medical Sciences Tehran Iran
  • Vahid Salimi
    Department of Virology, School of Public Health Tehran University of Medical Sciences Tehran Iran
  • Sayed Mahdi Marashi
    Department of Virology, School of Public Health Tehran University of Medical Sciences Tehran Iran

説明

<jats:title>Summary</jats:title><jats:p>The pleiotropic role of vitamin D has been explored over the past decades and there is compelling evidence for an epidemiological association between poor vitamin D status and a variety of diseases. While the potential anti‐viral effect of vitamin D has recently been described, the underlying mechanisms by which vitamin D deficiency could contribute to viral disease development remain poorly understood. The possible interactions between viral infections and vitamin D appear to be more complex than previously thought. Recent findings indicate a complex interplay between viral infections and vitamin D, including the induction of anti‐viral state, functional immunoregulatory features, interaction with cellular and viral factors, induction of autophagy and apoptosis, and genetic and epigenetic alterations. While crosstalk between vitamin D and intracellular signalling pathways may provide an essential modulatory effect on viral gene transcription, the immunomodulatory effect of vitamin D on viral infections appears to be transient. The interplay between viral infections and vitamin D remains an intriguing concept, and the global imprint that vitamin D can have on the immune signature in the context of viral infections is an area of growing interest.</jats:p>

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