The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology
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- Edmund R. S. Kunji
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom
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- Martin S. King
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom
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- Jonathan J. Ruprecht
- Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom
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- Chancievan Thangaratnarajah
- Groningen Biomolecular Sciences and Biotechnology Institute, Membrane Enzymology, University of Groningen, Groningen, The Netherlands
書誌事項
- 公開日
- 2020-09-01
- DOI
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- 10.1152/physiol.00009.2020
- 公開者
- American Physiological Society
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説明
<jats:p>Members of the mitochondrial carrier family (SLC25) transport a variety of compounds across the inner membrane of mitochondria. These transport steps provide building blocks for the cell and link the pathways of the mitochondrial matrix and cytosol. An increasing number of diseases and pathologies has been associated with their dysfunction. In this review, the molecular basis of these diseases is explained based on our current understanding of their transport mechanism.</jats:p>
収録刊行物
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- Physiology
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Physiology 35 (5), 302-327, 2020-09-01
American Physiological Society