Complementary Function and Integrated Wiring of the Evolutionarily Distinct<i>Drosophila</i>Olfactory Subsystems
書誌事項
- 公開日
- 2011-09-21
- 権利情報
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- https://creativecommons.org/licenses/by-nc-sa/4.0/
- DOI
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- 10.1523/jneurosci.2360-11.2011
- 公開者
- Society for Neuroscience
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説明
<jats:p>To sense myriad environmental odors, animals have evolved multiple, large families of divergent olfactory receptors. How and why distinct receptor repertoires and their associated circuits are functionally and anatomically integrated is essentially unknown. We have addressed these questions through comprehensive comparative analysis of the<jats:italic>Drosophila</jats:italic>olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs). We identify ligands for most IR neuron classes, revealing their specificity for select amines and acids, which complements the broader tuning of ORs for esters and alcohols. IR and OR sensory neurons exhibit glomerular convergence in segregated, although interconnected, zones of the primary olfactory center, but these circuits are extensively interdigitated in higher brain regions. Consistently, behavioral responses to odors arise from an interplay between IR- and OR-dependent pathways. We integrate knowledge on the different phylogenetic and developmental properties of these receptors and circuits to propose models for the functional contributions and evolution of these distinct olfactory subsystems.</jats:p>
収録刊行物
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- The Journal of Neuroscience
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The Journal of Neuroscience 31 (38), 13357-13375, 2011-09-21
Society for Neuroscience