Interaction Between Orexin‐A and Sleep Quality in Females in Extreme Weight Conditions

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  • Sarah Sauchelli
    Department of Psychiatry University Hospital of Bellvitge‐IDIBELL Barcelona Spain
  • Susana Jiménez‐Murcia
    Department of Psychiatry University Hospital of Bellvitge‐IDIBELL Barcelona Spain
  • Jose C. Fernández‐García
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Lourdes Garrido‐Sánchez
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Francisco J. Tinahones
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Felipe F. Casanueva
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Rosa M. Baños
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Cristina Botella
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Ana B. Crujeiras
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Rafael de la Torre
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Jose M. Fernández‐Real
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Gema Frühbeck
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Roser Granero
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Francisco J. Ortega
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Amaia Rodríguez
    CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) Instituto de Salud Carlos III Madrid Spain
  • Stephan Zipfel
    Department of Psychosomatic Medicine University of Tübingen Tübingen Germany
  • Katrin E. Giel
    Department of Psychosomatic Medicine University of Tübingen Tübingen Germany
  • Jose M. Menchón
    Department of Psychiatry University Hospital of Bellvitge‐IDIBELL Barcelona Spain
  • Fernando Fernández‐Aranda
    Department of Psychiatry University Hospital of Bellvitge‐IDIBELL Barcelona Spain

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<jats:title>Abstract</jats:title><jats:p>The current study examined the relationship between plasma orexin‐A and sleep in obesity. Concentrations of orexin‐A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy‐weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist‐90‐Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin‐A levels (<jats:italic>p</jats:italic> = .050), greater depression, anxiety and somatization symptoms (all: <jats:italic>p</jats:italic> < .001), and impoverished self‐reported sleep quality (<jats:italic>p</jats:italic> < .001). A quadratic trend was found in objective sleep time, being longest in the obese group (<jats:italic>p</jats:italic> = .031). Structural equation modelling showed plasma orexin‐A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin‐A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.</jats:p>

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