-
- Marc de Perrot
- Thoracic Surgery Research Laboratory, Pathobiology and Immunology, Toronto General Hospital Research Institute, University of Toronto , Toronto ,
-
- Kevin Young
- Departments of Laboratory Medicine, Pathobiology and Immunology, Toronto General Hospital Research Institute, University of Toronto , Toronto ,
-
- Yumiko Imai
- Thoracic Surgery Research Laboratory, Pathobiology and Immunology, Toronto General Hospital Research Institute, University of Toronto , Toronto ,
-
- Mingyao Liu
- Thoracic Surgery Research Laboratory, Pathobiology and Immunology, Toronto General Hospital Research Institute, University of Toronto , Toronto ,
-
- Thomas K Waddell
- Thoracic Surgery Research Laboratory, Pathobiology and Immunology, Toronto General Hospital Research Institute, University of Toronto , Toronto ,
-
- Stefan Fischer
- Thoracic Surgery Research Laboratory, Pathobiology and Immunology, Toronto General Hospital Research Institute, University of Toronto , Toronto ,
-
- Li Zhang
- Departments of Laboratory Medicine, Pathobiology and Immunology, Toronto General Hospital Research Institute, University of Toronto , Toronto ,
-
- Shaf Keshavjee
- Thoracic Surgery Research Laboratory, Pathobiology and Immunology, Toronto General Hospital Research Institute, University of Toronto , Toronto ,
書誌事項
- 公開日
- 2003-11
- 権利情報
-
- https://academic.oup.com/pages/standard-publication-reuse-rights
- DOI
-
- 10.4049/jimmunol.171.10.4995
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Leukocytes have been implicated in ischemia-reperfusion (IR) injury of the lung, but the individual role of T cells has not been explored. Recent evidence in mice suggests that T cells may play a role in IR injury. Using a syngeneic (Lewis to Lewis) rat lung transplant model, we observed that recipient CD4+ T cells infiltrated lung grafts within 1 h of reperfusion and up-regulated the expression of CD25 over the ensuing 12 h. Nude rats (rnu/rnu) and heterozygous rats (rnu/+) were used to determine the role of T cells in IR injury. No significant difference in lung function was observed between nude and heterozygous recipient rats after 2 h of reperfusion. However, after 12 h of reperfusion, recipient nude rats had significantly higher oxygenation and lower peak airway pressure than recipient heterozygous rats. This was associated with significantly lower levels of IFN-γ in transplanted lung tissue of recipient nude rats. Reconstitution of recipient nude rats with T cells from heterozygous rats restored IR injury after 12 h of reperfusion. The effect of T cells was independent of neutrophil recruitment and activation in the transplanted lung. These results demonstrate that recipient T cells are activated and mediate IR injury during lung transplantation in rats.</jats:p>
収録刊行物
-
- The Journal of Immunology
-
The Journal of Immunology 171 (10), 4995-5002, 2003-11
Oxford University Press (OUP)