Randomized Phase III Study Comparing Gefitinib With Erlotinib in Patients With Previously Treated Advanced Lung Adenocarcinoma: WJOG 5108L
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- Yoshiko Urata
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Nobuyuki Katakami
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Satoshi Morita
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Reiko Kaji
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Hiroshige Yoshioka
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Takashi Seto
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Miyako Satouchi
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Yasuo Iwamoto
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Masashi Kanehara
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Daichi Fujimoto
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Norihiko Ikeda
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Haruyasu Murakami
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Haruko Daga
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Tetsuya Oguri
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Isao Goto
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Fumio Imamura
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Shunichi Sugawara
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Hideo Saka
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Naoyuki Nogami
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Shunichi Negoro
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Kazuhiko Nakagawa
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
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- Yoichi Nakanishi
- Yoshiko Urata, Miyako Satouchi, and Shunichi Negoro, Hyogo Cancer Center, Akashi; Nobuyuki Katakami and Reiko Kaji, Institute of Biomedical Research and Innovation; Daichi Fujimoto, Kobe City Medical Center General Hospital, Kobe; Satoshi Morita, Kyoto University Graduate School of Medicine, Kyoto; Hiroshige Yoshioka, Kurashiki Central Hospital, Kurashiki; Takashi Seto, National Kyushu Cancer Center; Yoichi Nakanishi, Kyushu University, Graduate School of Medical Sciences, Fukuoka; Yasuo Iwamoto and...
抄録
<jats:sec><jats:title>Purpose</jats:title><jats:p> The epidermal growth factor receptor (EGFR) tyrosine kinase has been an important target for non–small-cell lung cancer. Several EGFR tyrosine kinase inhibitors (TKIs) are currently approved, and both gefitinib and erlotinib are the most well-known first-generation EGFR-TKIs. This randomized phase III study was conducted to investigate the difference between these two EGFR-TKIs. </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> Previously treated patients with lung adenocarcinoma were randomly assigned to receive gefitinib or erlotinib. This study aimed to investigate the noninferiority of gefitinib compared with erlotinib. The primary end point was progression-free survival (PFS). </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Five hundred sixty-one patients were randomly assigned, including 401 patients (71.7%) with EGFR mutation. All baseline factors (except performance status) were balanced between the arms. Median PFS and overall survival times for gefitinib and erlotinib were 6.5 and 7.5 months (hazard ratio [HR], 1.125; 95% CI, 0.940 to 1.347; P = .257) and 22.8 and 24.5 months (HR, 1.038; 95% CI, 0.833 to 1.294; P = .768), respectively. The response rates for gefitinib and erlotinib were 45.9% and 44.1%, respectively. Median PFS times in EGFR mutation–positive patients receiving gefitinib versus erlotinib were 8.3 and 10.0 months, respectively (HR, 1.093; 95% CI, 0.879 to 1.358; P = .424). The primary grade 3 or 4 toxicities were rash (2.2% for gefitinib v 18.1% for erlotinib) and alanine aminotransferase (ALT)/aspartate aminotransferase (AST) elevation (6.1%/13.0% for gefitinib v 2.2%/3.3% for erlotinib). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> The study did not demonstrate noninferiority of gefitinib compared with erlotinib in terms of PFS in patients with lung adenocarcinoma according to the predefined criteria. </jats:p></jats:sec>
収録刊行物
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- Journal of Clinical Oncology
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Journal of Clinical Oncology 34 (27), 3248-3257, 2016-09-20
American Society of Clinical Oncology (ASCO)