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- Sarah A. Thomson
- Centre for Paediatric Pharmacy Research
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- Catherine Tuleu
- Centre for Paediatric Pharmacy Research
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- Ian C. K. Wong
- Institute of Child Health, University College London, London, England
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- Simon Keady
- Department of Pharmaceutics, School of Pharmacy, University of London, London, England
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- Kendal G. Pitt
- Global Manufacturing Supplies, GlaxoSmithKline, Ware, England
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- Alastair G. Sutcliffe
- General and Adolescent Unit, University College Medical School
書誌事項
- 公開日
- 2009-02-01
- DOI
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- 10.1542/peds.2008-2059
- 公開者
- American Academy of Pediatrics (AAP)
この論文をさがす
説明
<jats:p>OBJECTIVE. The goal was to assess the acceptability and suitability of placebo minitablets for preschool-aged children.</jats:p> <jats:p>METHODS. One hundred children 2 to 6 years of age were recruited from a major London hospital. How to swallow the minitablet was discussed with the child, and chewing was discouraged. The parents were asked to administer 1 minitablet (placebo, 3-mm diameter) to the child. The outcomes were recorded as (1) swallowed, (2) chewed, (3) spat out, or (4) refused to take.</jats:p> <jats:p>RESULTS. Of the youngest children (2 years of age), almost one half (46%) swallowed the minitablet. The proportion increased to 53% for children 3 years of age. Children ≥4 years of age were more likely to swallow the minitablet than not to swallow the minitablet, with 85% of 5-year-old children swallowing the minitablet. The ability to swallow the minitablet was not affected by gender.</jats:p> <jats:p>CONCLUSIONS. This study demonstrated the potential to use minitablets for the treatment of preschool-aged children and suggests that minitablets can be used as a potential new formulation for children in this age range.</jats:p>
収録刊行物
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- Pediatrics
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Pediatrics 123 (2), e235-e238, 2009-02-01
American Academy of Pediatrics (AAP)