Insulin Across Respiratory Mucosae by Aerosol Delivery

  • Frederick M Wigley
    Departments of Medicine and Microbiology, University of Florida College of Medicine Gainesville, Florida 32601
  • Javier H Londono
    Departments of Medicine and Microbiology, University of Florida College of Medicine Gainesville, Florida 32601
  • Scott H Wood
    Departments of Medicine and Microbiology, University of Florida College of Medicine Gainesville, Florida 32601
  • Joseph C Shipp
    Departments of Medicine and Microbiology, University of Florida College of Medicine Gainesville, Florida 32601
  • Robert H Waldman
    Departments of Medicine and Microbiology, University of Florida College of Medicine Gainesville, Florida 32601

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説明

<jats:p>Insulin, a protein of about 5,700 molecular weight, was delivered by aerosol inhalation to three normal volunteers and to four patients with diabetes mellitus. Direct evidence of absorption of insulin across mucosae of the respiratory tract was an increase in plasma IRI. Biologic activity of insulin absorbed by inhalation was shown by hypoglycemia temporally correlated with the increase in plasma IRI. No untoward reactions were observed.</jats:p>

収録刊行物

  • Diabetes

    Diabetes 20 (8), 552-556, 1971-08-01

    American Diabetes Association

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