Novel RNA Modifications in the Nervous System: Form and Function

John S. Satterlee, Maria Basanta-Sanchez, Sandra Blanco, Jin Billy Li, Kate Meyer, Jonathan Pollock, Ghazaleh Sadri-Vakili, Agnieszka Rybak-Wolf

doi:10.1523/jneurosci.3236-14.2014

Novel RNA Modifications in the Nervous System: Form and Function

説明

<jats:p>Modified RNA molecules have recently been shown to regulate nervous system functions. This mini-review and associated mini-symposium provide an overview of the types and known functions of novel modified RNAs in the nervous system, including covalently modified RNAs, edited RNAs, and circular RNAs. We discuss basic molecular mechanisms involving RNA modifications as well as the impact of modified RNAs and their regulation on neuronal processes and disorders, including neural fate specification, intellectual disability, neurodegeneration, dopamine neuron function, and substance use disorders.</jats:p>