Getting Drugs Across Biological Barriers

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  • Rong Yang
    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Children's Hospital Boston Harvard Medical School 300 Longwood Avenue Boston MA 02115 USA
  • Tuo Wei
    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Children's Hospital Boston Harvard Medical School 300 Longwood Avenue Boston MA 02115 USA
  • Hannah Goldberg
    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Children's Hospital Boston Harvard Medical School 300 Longwood Avenue Boston MA 02115 USA
  • Weiping Wang
    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Children's Hospital Boston Harvard Medical School 300 Longwood Avenue Boston MA 02115 USA
  • Kathleen Cullion
    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Children's Hospital Boston Harvard Medical School 300 Longwood Avenue Boston MA 02115 USA
  • Daniel S. Kohane
    Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Children's Hospital Boston Harvard Medical School 300 Longwood Avenue Boston MA 02115 USA

Description

<jats:p>The delivery of drugs to a target site frequently involves crossing biological barriers. The degree and nature of the impediment to flux, as well as the potential approaches to overcoming it, depend on the tissue, the drug, and numerous other factors. Here an overview of approaches that have been taken to crossing biological barriers is presented, with special attention to transdermal drug delivery. Technology and knowledge pertaining to addressing these issues in a variety of organs could have a significant clinical impact.</jats:p>

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