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- Yu Chen
- Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.
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- Ross Corriden
- Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.
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- Yoshiaki Inoue
- Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.
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- Linda Yip
- Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.
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- Naoyuki Hashiguchi
- Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.
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- Annelies Zinkernagel
- Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.
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- Victor Nizet
- Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.
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- Paul A. Insel
- Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.
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- Wolfgang G. Junger
- Department of Surgery, University of California San Diego, San Diego, CA 92103, USA.
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説明
<jats:p>Cells must amplify external signals to orient and migrate in chemotactic gradient fields. We find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of the cell surface to amplify chemotactic signals and direct cell orientation by feedback through P2Y2 nucleotide receptors. Neutrophils rapidly hydrolyze released ATP to adenosine that then acts via A3-type adenosine receptors, which are recruited to the leading edge, to promote cell migration. Thus, ATP release and autocrine feedback through P2Y2 and A3 receptors provide signal amplification, controlling gradient sensing and migration of neutrophils.</jats:p>
収録刊行物
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- Science
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Science 314 (5806), 1792-1795, 2006-12-15
American Association for the Advancement of Science (AAAS)