The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America

  • Gary P. Wormser
    Divisions of Infectious Diseases and New York University School of Medicine, New York, New York
  • Raymond J. Dattwyler
    Divisions of Allergy, Immunology, and Rheumatology, Department of Medicine, New York Medical College, Valhalla, and New York University School of Medicine, New York, New York
  • Eugene D. Shapiro
    Departments of Pediatrics and Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children's Medical Center, Hartford
  • John J. Halperin
    Divisions of New York University School of Medicine, New York, New York
  • Allen C. Steere
    Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, and Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts
  • Mark S. Klempner
    Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts
  • Peter J. Krause
    Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children's Medical Center, Hartford
  • Johan S. Bakken
    Section of Infectious Diseases, St. Luke's Hospital, Duluth, Minnesota
  • Franc Strle
    Department of Infectious Diseases, University Medical Center, Ljubljana, Slovenia
  • Gerold Stanek
    Medical University of Vienna, Vienna, Austria
  • Linda Bockenstedt
    Departments of Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, and Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children's Medical Center, Hartford
  • Durland Fish
    Departments of Epidemiology and Public Health and Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children's Medical Center, Hartford
  • J. Stephen Dumler
    Division of Medical Microbiology, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland
  • Robert B. Nadelman
    Divisions of Infectious Diseases and New York University School of Medicine, New York, New York

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<jats:title>Abstract</jats:title><jats:p>Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases Society of America. These updated guidelines replace the previous treatment guidelines published in 2000 (Clin Infect Dis 2000; 31[Suppl 1]:1–14). The guidelines are intended for use by health care providers who care for patients who either have these infections or may be at risk for them. For each of these Ixodes tickborne infections, information is provided about prevention, epidemiology, clinical manifestations, diagnosis, and treatment. Tables list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided. A definition of post–Lyme disease syndrome is proposed.</jats:p>

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