Low-dose, simple, and fast grating-based X-ray phase-contrast imaging

  • Peiping Zhu
    Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China;
  • Kai Zhang
    Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China;
  • Zhili Wang
    Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China;
  • Yijin Liu
    Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China;
  • Xiaosong Liu
    Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China;
  • Ziyu Wu
    Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China;
  • Samuel A. McDonald
    Swiss Light Source, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland;
  • Federica Marone
    Swiss Light Source, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland;
  • Marco Stampanoni
    Swiss Light Source, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland;

抄録

<jats:p>Phase sensitive X-ray imaging methods can provide substantially increased contrast over conventional absorption-based imaging and therefore new and otherwise inaccessible information. The use of gratings as optical elements in hard X-ray phase imaging overcomes some of the problems that have impaired the wider use of phase contrast in X-ray radiography and tomography. So far, to separate the phase information from other contributions detected with a grating interferometer, a phase-stepping approach has been considered, which implies the acquisition of multiple radiographic projections. Here we present an innovative, highly sensitive X-ray tomographic phase-contrast imaging approach based on grating interferometry, which extracts the phase-contrast signal without the need of phase stepping. Compared to the existing phase-stepping approach, the main advantages of this new method dubbed “reverse projection” are not only the significantly reduced delivered dose, without the degradation of the image quality, but also the much higher efficiency. The new technique sets the prerequisites for future fast and low-dose phase-contrast imaging methods, fundamental for imaging biological specimens and in vivo studies.</jats:p>

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