Soluble Glycoprotein VI Is Raised in the Plasma of Patients With Acute Ischemic Stroke

DOI Web Site 5 Citations
  • Mohammad Al-Tamimi
    From the Australian Centre for Blood Diseases (M.A.T., E.E.G., Y.S., R.K.A.), Monash University, Melbourne, Australia; the University of Western Australia (M.N.C.), Perth, Australia; Dublin City University (M.C.B.), Dublin, UK; Royal Perth Hospital (J.Y.T., G.J.H., R.I.B.), Perth, Australia; and the Centre for Thrombosis and Haemophilia (R.I.B.), Murdoch University, Perth, Australia.
  • Elizabeth E. Gardiner
    From the Australian Centre for Blood Diseases (M.A.T., E.E.G., Y.S., R.K.A.), Monash University, Melbourne, Australia; the University of Western Australia (M.N.C.), Perth, Australia; Dublin City University (M.C.B.), Dublin, UK; Royal Perth Hospital (J.Y.T., G.J.H., R.I.B.), Perth, Australia; and the Centre for Thrombosis and Haemophilia (R.I.B.), Murdoch University, Perth, Australia.
  • Jim Y. Thom
    From the Australian Centre for Blood Diseases (M.A.T., E.E.G., Y.S., R.K.A.), Monash University, Melbourne, Australia; the University of Western Australia (M.N.C.), Perth, Australia; Dublin City University (M.C.B.), Dublin, UK; Royal Perth Hospital (J.Y.T., G.J.H., R.I.B.), Perth, Australia; and the Centre for Thrombosis and Haemophilia (R.I.B.), Murdoch University, Perth, Australia.
  • Yang Shen
    From the Australian Centre for Blood Diseases (M.A.T., E.E.G., Y.S., R.K.A.), Monash University, Melbourne, Australia; the University of Western Australia (M.N.C.), Perth, Australia; Dublin City University (M.C.B.), Dublin, UK; Royal Perth Hospital (J.Y.T., G.J.H., R.I.B.), Perth, Australia; and the Centre for Thrombosis and Haemophilia (R.I.B.), Murdoch University, Perth, Australia.
  • Matthew N. Cooper
    From the Australian Centre for Blood Diseases (M.A.T., E.E.G., Y.S., R.K.A.), Monash University, Melbourne, Australia; the University of Western Australia (M.N.C.), Perth, Australia; Dublin City University (M.C.B.), Dublin, UK; Royal Perth Hospital (J.Y.T., G.J.H., R.I.B.), Perth, Australia; and the Centre for Thrombosis and Haemophilia (R.I.B.), Murdoch University, Perth, Australia.
  • Graeme J. Hankey
    From the Australian Centre for Blood Diseases (M.A.T., E.E.G., Y.S., R.K.A.), Monash University, Melbourne, Australia; the University of Western Australia (M.N.C.), Perth, Australia; Dublin City University (M.C.B.), Dublin, UK; Royal Perth Hospital (J.Y.T., G.J.H., R.I.B.), Perth, Australia; and the Centre for Thrombosis and Haemophilia (R.I.B.), Murdoch University, Perth, Australia.
  • Michael C. Berndt
    From the Australian Centre for Blood Diseases (M.A.T., E.E.G., Y.S., R.K.A.), Monash University, Melbourne, Australia; the University of Western Australia (M.N.C.), Perth, Australia; Dublin City University (M.C.B.), Dublin, UK; Royal Perth Hospital (J.Y.T., G.J.H., R.I.B.), Perth, Australia; and the Centre for Thrombosis and Haemophilia (R.I.B.), Murdoch University, Perth, Australia.
  • Ross I. Baker
    From the Australian Centre for Blood Diseases (M.A.T., E.E.G., Y.S., R.K.A.), Monash University, Melbourne, Australia; the University of Western Australia (M.N.C.), Perth, Australia; Dublin City University (M.C.B.), Dublin, UK; Royal Perth Hospital (J.Y.T., G.J.H., R.I.B.), Perth, Australia; and the Centre for Thrombosis and Haemophilia (R.I.B.), Murdoch University, Perth, Australia.
  • Robert K. Andrews
    From the Australian Centre for Blood Diseases (M.A.T., E.E.G., Y.S., R.K.A.), Monash University, Melbourne, Australia; the University of Western Australia (M.N.C.), Perth, Australia; Dublin City University (M.C.B.), Dublin, UK; Royal Perth Hospital (J.Y.T., G.J.H., R.I.B.), Perth, Australia; and the Centre for Thrombosis and Haemophilia (R.I.B.), Murdoch University, Perth, Australia.

Abstract

<jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p>Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p>We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects.</jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> sGPVI was elevated in stroke compared with controls ( <jats:italic>P</jats:italic> =0.0168). ORs were higher in Quartile 4 for stroke cases ( <jats:italic>P</jats:italic> =0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin ( <jats:italic>P</jats:italic> =0.0007) and was higher in individuals with the GPVI <jats:italic>a</jats:italic> haplotype ( <jats:italic>P</jats:italic> =0.024). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion—</jats:title> <jats:p>Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.</jats:p> </jats:sec>

Journal

  • Stroke

    Stroke 42 (2), 498-500, 2011-02

    Ovid Technologies (Wolters Kluwer Health)

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