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- Florian Mayr
- Department Chemie and Catalysis Research Center (CRC), Technische Universität München
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- Lisa-Marie Mohr
- Department Chemie and Catalysis Research Center (CRC), Technische Universität München
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- Elsa Rodriguez
- Department Chemie and Catalysis Research Center (CRC), Technische Universität München
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- Thorsten Bach
- Department Chemie and Catalysis Research Center (CRC), Technische Universität München
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説明
<jats:p>Four different 1-aminocyclohexanes bearing a tethered thioxanthone group in the 2-position were prepared. The synthesis commenced with the respective N-protected β-amino acids, the carboxyl group of which was employed for the introduction of the thioxanthone moiety. After construction of the thioxanthone and protecting group removal, the conversion of the amino group into the respective thiourea was accomplished by treatment with N-3,5-bis(trifluoromethyl)phenyl isothiocyanate and yielded the title compounds in which the thioxanthone resides in different spatial positions relative to the thiourea motif. Overall yields varied between 20–35%.</jats:p>
収録刊行物
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- Synthesis
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Synthesis 49 (23), 5238-5250, 2017-10-19
Georg Thieme Verlag KG