High pressure macromolecular crystallography for structural biology: a review
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- Katarzyna Kurpiewska
- Protein Crystallography Group, Department of Crystal Physics and Crystal Chemistry, Faculty of Chemistry, Jagiellonian University, 30-060, Kraków, Poland
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- Krzysztof Lewiński
- Protein Crystallography Group, Department of Crystal Physics and Crystal Chemistry, Faculty of Chemistry, Jagiellonian University, 30-060, Kraków, Poland
抄録
<jats:title>Abstract</jats:title> <jats:p>In recent years, significant progress in high pressure macromolecular crystallography has been observed. It can be attributed both to the developments in experimental techniques, as well as to recognition of importance of high pressure protein studies in biochemistry and biophysics. The number of protein structures determined at pressure up to 1 GPa is growing. The unique advantages of this method can greatly improve the investigation of higher energy conformers of functional significance and our understanding of functionally important conformers, protein folding processes and the structural base of conformational diseases.</jats:p>
収録刊行物
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- Open Life Sciences
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Open Life Sciences 5 (5), 531-542, 2010-08-20
Walter de Gruyter GmbH