Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53
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- Kyoung Wan Yoon
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
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- Sanguine Byun
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
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- Eunjeong Kwon
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
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- So-Young Hwang
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
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- Kiki Chu
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
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- Masatsugu Hiraki
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
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- Seung-Hee Jo
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
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- Astrid Weins
- Department of Pathology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115, USA.
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- Samy Hakroush
- Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
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- Angelika Cebulla
- Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
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- David B. Sykes
- Center for Regenerative Medicine and Technology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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- Anna Greka
- Department of Medicine, Glom-NExT Center for Glomerular Kidney Disease and Novel Experimental Therapeutics, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115, USA.
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- Peter Mundel
- Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
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- David E. Fisher
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
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- Anna Mandinova
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
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- Sam W. Lee
- Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
書誌事項
- 公開日
- 2015-07-31
- 権利情報
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- http://www.sciencemag.org/about/science-licenses-journal-article-reuse
- DOI
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- 10.1126/science.1261669
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Tumor suppressor p53 linked to immune function</jats:title> <jats:p> We thought we knew all we needed to about the tumor suppressor p53. However, Yoon <jats:italic>et al.</jats:italic> now describe a previously unrecognized function of p53 (see the Perspective by Zitvogel and Kroemer). p53 induces expression of the gene encoding DD1α, a receptor-like transmembrane protein of the immunoglobulin superfamily. In conditions of stress, p53 activation can lead to cell death. p53-induced expression of DD1α also promotes the clearance of dead cells by promoting engulfment by macrophages. Furthermore, expression of DD1α on T cells inhibits T cell function. Thus, p53 offers protection from inflammatory disease caused by the accumulation of apoptotic cells, and its suppression of T cells might help cancer cells to escape immune detection. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1261669">10.1126/science.1261669</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6247" page="476" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aac8475">476</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 349 (6247), 1261669-, 2015-07-31
American Association for the Advancement of Science (AAAS)