Immune Characteristics of the Beige‐Nude Mouse

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書誌事項

タイトル別名
  • A Model for Studying Immune Surveillance
公開日
1984-09
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1111/j.1365-3083.1984.tb01002.x
公開者
Wiley

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説明

<jats:p>Double immunodeficient mice, homozygous for both the beige and the nude genes, were developed on C57B1/6N‐beige and N :NIH(S)‐nude background through five steps of mating. The animals were healthy and had a life span comparable to that of regular nude mice. Beige and regular nude mice showed a significant difference in natural killer (NK) activity, with mean±SE values of 6±1.0% and 25±2.8%, respectively. The response to the T ‐cell mitogens phytohaemagglutinin and concanavalin A was similar in beige and NIH mice of the same genotypes for the nude genes. Both groups of nu/nu mice also showed some response in these assays, as well as in the plaque‐forming cell assay, indicating that nude mice are not completely devoid of functional T or T‐like cells. The nude genes were found to increase the response to the B‐cell mitogen lipopolysaccharide in both the beige and NIH animals, whereas the response was reduced in mice of the beige genotypes. The viable, low NK beige‐nude mice here reported on may be a valuable tool for studying factors involved in host defence against tumours. Interestingly, no spontaneous tumours have so far been observed in such mice.</jats:p>

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