Tonic GABA<sub>A</sub> receptor‐mediated currents in human brain

Annalisa Scimemi, Anna Andersson, Joost H. Heeroma, Joakim Strandberg, Bertil Rydenhag, Andrew W. McEvoy, Maria Thom, Fredrik Asztely, Matthew C. Walker

doi:10.1111/j.1460-9568.2006.04989.x

Tonic GABA<sub>A</sub> receptor‐mediated currents in human brain

DOI Web Site Web Site 被引用文献1件

書誌事項

公開日: 2006-08

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http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1111/j.1460-9568.2006.04989.x

公開者: Wiley

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<jats:title>Abstract</jats:title><jats:p>GABA<jats:sub>A</jats:sub> receptors can mediate both phasic (synaptic) and tonic (extrasynaptic) forms of inhibition. It has been proposed that tonic inhibition plays a critical part in controlling neuronal and network excitability. Although tonic GABA<jats:sub>A</jats:sub> receptor‐mediated currents have been well characterized in rodents, their existence in human tissue has yet to be demonstrated. Here we show that tonic currents can be recorded from human tissue obtained from patients undergoing temporal lobectomies. Tonic GABA<jats:sub>A</jats:sub> receptor‐mediated currents were present in pyramidal cells and interneurons in layer V‐VI of temporal neocortex and granule cells in the dentate gyrus. These tonic currents have cell type‐specific pharmacologies, opening up the possibility of targeted therapeutics.</jats:p>