Electric‐Field‐Assisted Growth of Functionalized Poly(3,4‐ethylenedioxythiophene) Nanowires for Label‐Free Protein Detection
書誌事項
- 公開日
- 2009-11-11
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/smll.200900312
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>The construction of functionalized poly(3,4‐ethylenedioxythiophene) (PEDOT) nanowire devices for label‐free protein detection is reported. Direct growth/assembly of PEDOT nanowires with carboxylic acid side‐chain functional groups (poly(EDOT‐COOH)) across the electrode junction is achieved by using an electric‐field‐assisted method. These functionalized PEDOT nanowire devices show typical depletion‐mode p‐type field‐effect transistor (FET) properties. Upon conjugation with a protein‐binding aptamer, the PEDOT nanowire FET devices are used for label‐free electronic detection of a target protein of interest. The binding of a positively charged protein causes a substantial decrease in current flow, attributed to the specific interaction between target protein molecules and aptamer‐conjugated polymer chains.</jats:p>
収録刊行物
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- Small
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Small 5 (22), 2611-2617, 2009-11-11
Wiley