A genome-wide resource of cell cycle and cell shape genes of fission yeast
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- Jacqueline Hayles
- Cell Cycle Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK
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- Valerie Wood
- Cell Cycle Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK
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- Linda Jeffery
- Cell Cycle Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK
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- Kwang-Lae Hoe
- Department of New Drug Discovery and Development, Chungnam National University, Yusong, Daejeon, South Korea
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- Dong-Uk Kim
- Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon, South Korea
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- Han-Oh Park
- Bioneer Corporation, Daedeok, Daejeon, South Korea
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- Silvia Salas-Pino
- Laboratory of Yeast Cell Biology and Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA
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- Christian Heichinger
- Laboratory of Yeast Cell Biology and Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA
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- Paul Nurse
- Cell Cycle Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK
説明
<jats:p>To identify near complete sets of genes required for the cell cycle and cell shape, we have visually screened a genome-wide gene deletion library of 4843 fission yeast deletion mutants (95.7% of total protein encoding genes) for their effects on these processes. A total of 513 genes have been identified as being required for cell cycle progression, 276 of which have not been previously described as cell cycle genes. Deletions of a further 333 genes lead to specific alterations in cell shape and another 524 genes result in generally misshapen cells. Here, we provide the first eukaryotic resource of gene deletions, which describes a near genome-wide set of genes required for the cell cycle and cell shape.</jats:p>
収録刊行物
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- Open Biology
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Open Biology 3 (5), 130053-, 2013-05
The Royal Society
