Glioma‐Targeted Delivery of a Theranostic Liposome Integrated with Quantum Dots, Superparamagnetic Iron Oxide, and Cilengitide for Dual‐Imaging Guiding Cancer Surgery
-
- He‐Lin Xu
- Department of Pharmaceutics School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou City Zhejiang Province 325035 China
-
- Jing‐Jing Yang
- Department of Pharmaceutics School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou City Zhejiang Province 325035 China
-
- De‐Li ZhuGe
- Department of Pharmaceutics School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou City Zhejiang Province 325035 China
-
- Meng‐Ting Lin
- Department of Pharmaceutics School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou City Zhejiang Province 325035 China
-
- Qun‐Yan Zhu
- Department of Pharmaceutics School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou City Zhejiang Province 325035 China
-
- Bing‐Hui Jin
- Department of Pharmaceutics School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou City Zhejiang Province 325035 China
-
- Meng‐Qi Tong
- Department of Pharmaceutics School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou City Zhejiang Province 325035 China
-
- Bi‐Xin Shen
- Department of Pharmaceutics School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou City Zhejiang Province 325035 China
-
- Jian Xiao
- Key Laboratory of Biotechnology and Pharmaceutical Engineering School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou Zhejiang Province 325035 China
-
- Ying‐Zheng Zhao
- Department of Pharmaceutics School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou City Zhejiang Province 325035 China
説明
<jats:title>Abstract</jats:title><jats:p>Herein, a theranostic liposome (QSC‐Lip) integrated with superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) and cilengitide (CGT) into one platform is constructed to target glioma under magnetic targeting (MT) for guiding surgical resection of glioma. Transmission electron microscopy and X‐ray photoelectron spectroscopy confirm the complete coencapsulation of SPIONs and QDs in liposome. Besides, CGT is also effectively encapsulated into the liposome with an encapsulation efficiency of ∼88.9%. QSC‐Lip exhibits a diameter of 100 ± 1.24 nm, zeta potential of −17.10 ± 0.11 mV, and good stability in several mediums. Moreover, each cargo shows a biphasic release pattern from QSC‐Lip, a rapid initial release within initial 10 h followed by a sustained release. Cellular uptake of QSC‐Lip is significantly enhanced by C<jats:sub>6</jats:sub> cells under MT. In vivo dual‐imaging studies show that QSC‐Lip not only produces an obvious negative‐contrast enhancement effect on glioma by magnetic resonance imaging but also makes tumor emitting fluorescence under MT. The dual‐imaging of QSC‐Lip guides the accurate resection of glioma by surgery. Besides, CGT is also specifically distributed to glioma after administration of QSC‐Lip under MT, resulting in an effective inhibition of tumors. The integrated liposome may be a potential carrier for theranostics of tumor.</jats:p>
収録刊行物
-
- Advanced Healthcare Materials
-
Advanced Healthcare Materials 7 (9), 2018-01-19
Wiley