Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior
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- Emily A. Ferenczi
- Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
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- Kelly A. Zalocusky
- Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
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- Conor Liston
- Brain Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA.
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- Logan Grosenick
- Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
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- Melissa R. Warden
- Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA.
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- Debha Amatya
- Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
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- Kiefer Katovich
- Department of Psychology, Stanford University, Stanford, CA 94305, USA.
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- Hershel Mehta
- Department of Psychology, Stanford University, Stanford, CA 94305, USA.
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- Brian Patenaude
- Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
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- Charu Ramakrishnan
- Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
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- Paul Kalanithi
- Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
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- Amit Etkin
- Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
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- Brian Knutson
- Department of Psychology, Stanford University, Stanford, CA 94305, USA.
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- Gary H. Glover
- Department of Radiology, Stanford University, Stanford, CA, 94305, USA.
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- Karl Deisseroth
- Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
説明
<jats:title>A way to modulate reward-seeking</jats:title> <jats:p> Which brain regions are causally involved in reward-related behavior? Ferenczi <jats:italic>et al.</jats:italic> combined focal, cell type-specific, optogenetic manipulations with brain imaging, behavioral testing, and in vivo electrophysiology (see the Perspective by Robbins). Stimulation of midbrain dopamine neurons increased activity in a brain region called the striatum and was correlated with reward-seeking across individual animals. However, elevated excitability of an area called the medial prefrontal cortex reduced both striatal responses to the stimulation of dopamine neurons and the behavioral drive to seek the stimulation of dopamine neurons. Finally, modulating the excitability of medial prefrontal cortex pyramidal neurons drove changes in neural circuit synchrony, as well as corresponding anhedonic behavior. These observations resemble imaging and clinical phenotypes observed in human depression, addiction, and schizophrenia. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aac9698">10.1126/science.aac9698</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad9698">10.1126/science.aad9698</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 351 (6268), aac9698-, 2016-01
American Association for the Advancement of Science (AAAS)
