Coordinated Effects of Sequence Variation on DNA Binding, Chromatin Structure, and Transcription
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- Helena Kilpinen
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
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- Sebastian M. Waszak
- Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
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- Andreas R. Gschwind
- Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
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- Sunil K. Raghav
- Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
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- Robert M. Witwicki
- Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
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- Andrea Orioli
- Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
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- Eugenia Migliavacca
- Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
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- Michaël Wiederkehr
- Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
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- Maria Gutierrez-Arcelus
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
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- Nikolaos I. Panousis
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
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- Alisa Yurovsky
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
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- Tuuli Lappalainen
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
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- Luciana Romano-Palumbo
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
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- Alexandra Planchon
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
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- Deborah Bielser
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
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- Julien Bryois
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
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- Ismael Padioleau
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
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- Gilles Udin
- Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
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- Sarah Thurnheer
- Protein Expression Core Facility, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
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- David Hacker
- Protein Expression Core Facility, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
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- Leighton J. Core
- Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
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- John T. Lis
- Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
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- Nouria Hernandez
- Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
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- Alexandre Reymond
- Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
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- Bart Deplancke
- Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
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- Emmanouil T. Dermitzakis
- Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
説明
<jats:title>DNA Differences</jats:title> <jats:p> The extent to which genetic variation affects an individual's phenotype has been difficult to predict because the majority of variation lies outside the coding regions of genes. Now, three studies examine the extent to which genetic variation affects the chromatin of individuals with diverse ancestry and genetic variation (see the Perspective by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6159" page="705" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1246755"> <jats:bold>Furey and Sethupathy</jats:bold> </jats:related-article> ). <jats:bold> Kasowski <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6159" page="750" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1242510">750</jats:related-article> , published online 17 October) examined how genetic variation affects differences in chromatin states and their correlation to histone modifications, as well as more general DNA binding factors. <jats:bold> Kilpinen <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6159" page="744" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1242463">744</jats:related-article> , published online 17 October) document how genetic variation is linked to allelic specificity in transcription factor binding, histone modifications, and transcription. <jats:bold> McVicker <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6159" page="747" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1242429">747</jats:related-article> , published online 17 October) identified how quantitative trait loci affect histone modifications in Yoruban individuals and established which specific transcription factors affect such modifications. </jats:p>
収録刊行物
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- Science
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Science 342 (6159), 744-747, 2013-11-08
American Association for the Advancement of Science (AAAS)
