Regulation of Kainate Receptors by cAMP-Dependent Protein Kinase and Phosphatases
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- Lu-Yang Wang
- Departments of Physiology and Pharmacology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada M5S 1A8.
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- M. W. Salter
- Division of Neuroscience, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
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- J. F. MacDonald
- Departments of Physiology and Pharmacology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada M5S 1A8.
書誌事項
- 公開日
- 1991-09-06
- DOI
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- 10.1126/science.1653455
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:p>In the mammalian central nervous system, receptors for excitatory amino acid neurotransmitters such as the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-kainate receptor mediate a large fraction of excitatory transmission. Currents induced by activation of the AMPA-kainate receptor were potentiated by agents that specifically stimulate adenosine 3′,5′-monophosphate (cAMP)-dependent protein kinase A (PKA) activity or were supported by intracellular application of the catalytic subunit of PKA by itself or in combination with cAMP. Furthermore, depression of these currents by a competitive inhibitor of PKA indicates that AMPA-kainate receptors are regulated by endogenous PKA. Endogenous protein phosphatases also regulate these receptors because an inhibitor of cellular phosphatases enhanced kainate currents. Modulation of PKA and phosphatases may regulate the function of these receptors and thus contribute to synaptic plasticity in hippocampal neurons.</jats:p>
収録刊行物
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- Science
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Science 253 (5024), 1132-1135, 1991-09-06
American Association for the Advancement of Science (AAAS)