Opportunities and Challenges: Stem Cell‐Based Therapy for the Treatment of Ischemic Stroke

Yao‐Hui Tang, Yuan‐Yuan Ma, Zhi‐Jun Zhang, Yong‐Ting Wang, Guo‐Yuan Yang

doi:10.1111/cns.12386

Opportunities and Challenges: Stem Cell‐Based Therapy for the Treatment of Ischemic Stroke

DOI Web Site Web Site 被引用文献1件

Yao‐Hui Tang

Neuroscience and Neuroengineering Center Med‐X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China
Yuan‐Yuan Ma

Department of Neurology Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China
Zhi‐Jun Zhang

Neuroscience and Neuroengineering Center Med‐X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China
Yong‐Ting Wang

Neuroscience and Neuroengineering Center Med‐X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China
Guo‐Yuan Yang

Neuroscience and Neuroengineering Center Med‐X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China

書誌事項

公開日: 2015-02-10

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1111/cns.12386

公開者: Wiley

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説明

<jats:title>Summary</jats:title><jats:p>Stem cell‐based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell‐based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell‐based therapy is still in its infancy. The next decade of stem cell research in stroke field needs to focus on combining different stem cells and different imaging modalities to fully explore the potential of this therapeutic avenue: from bench to bedside and vice versa.</jats:p>