The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

  • Nicolas Stransky
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Ann Marie Egloff
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.
  • Aaron D. Tward
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Aleksandar D. Kostic
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Kristian Cibulskis
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Andrey Sivachenko
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Gregory V. Kryukov
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Michael S. Lawrence
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Carrie Sougnez
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Aaron McKenna
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Erica Shefler
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Alex H. Ramos
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Petar Stojanov
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Scott L. Carter
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Douglas Voet
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Maria L. Cortés
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Daniel Auclair
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Michael F. Berger
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Gordon Saksena
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Candace Guiducci
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Robert C. Onofrio
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Melissa Parkin
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Marjorie Romkes
    Department of Medicine, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15261, USA.
  • Joel L. Weissfeld
    Department of Epidemiology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.
  • Raja R. Seethala
    Department of Pathology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.
  • Lin Wang
    Department of Pathology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.
  • Claudia Rangel-Escareño
    Instituto Nacional de Medicina Genómica, Mexico City, 01900, Mexico.
  • Juan Carlos Fernandez-Lopez
    Instituto Nacional de Medicina Genómica, Mexico City, 01900, Mexico.
  • Alfredo Hidalgo-Miranda
    Instituto Nacional de Medicina Genómica, Mexico City, 01900, Mexico.
  • Jorge Melendez-Zajgla
    Instituto Nacional de Medicina Genómica, Mexico City, 01900, Mexico.
  • Wendy Winckler
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Kristin Ardlie
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Stacey B. Gabriel
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Matthew Meyerson
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Eric S. Lander
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Gad Getz
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Todd R. Golub
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Levi A. Garraway
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Jennifer R. Grandis
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

書誌事項

公開日
2011-08-26
DOI
  • 10.1126/science.1208130
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>The mutational profile of head and neck cancer is complex and may pose challenges to the development of targeted therapies.</jats:p>

収録刊行物

  • Science

    Science 333 (6046), 1157-1160, 2011-08-26

    American Association for the Advancement of Science (AAAS)

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