Genomic Analyses of Acute Flaccid Myelitis Cases among a Cluster in Arizona Provide Further Evidence of Enterovirus D68 Role
-
- Jolene R. Bowers
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- Michael Valentine
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- Veronica Harrison
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- Viacheslav Y. Fofanov
- School of Informatics Computing and Cyber Systems, Northern Arizona University, Flagstaff, Arizona, USA
-
- John Gillece
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- Josie Delisle
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- Bethany Patton
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- James Schupp
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- Krystal Sheridan
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- Darrin Lemmer
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- Scott Ostdiek
- Phoenix Children’s Hospital, Phoenix, Arizona, USA
-
- Harlori K. Bains
- Phoenix Children’s Hospital, Phoenix, Arizona, USA
-
- Jennifer Heim
- Phoenix Children’s Hospital, Phoenix, Arizona, USA
-
- Tammy Sylvester
- Maricopa County Department of Public Health, Phoenix, Arizona, USA
-
- Siru Prasai
- Maricopa County Department of Public Health, Phoenix, Arizona, USA
-
- Melissa Kretschmer
- Maricopa County Department of Public Health, Phoenix, Arizona, USA
-
- Nicole Fowle
- Maricopa County Department of Public Health, Phoenix, Arizona, USA
-
- Kenneth Komatsu
- Arizona Department of Health Services, Phoenix, Arizona, USA
-
- Shane Brady
- Arizona Department of Health Services, Phoenix, Arizona, USA
-
- Susan Robinson
- Arizona Department of Health Services, Phoenix, Arizona, USA
-
- Kathryn Fitzpatrick
- Arizona Department of Health Services, Phoenix, Arizona, USA
-
- Gholamabbas Amin Ostovar
- Maricopa Integrated Health System, Phoenix, Arizona, USA
-
- Eric Alsop
- Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA
-
- Elizabeth Hutchins
- Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA
-
- Kendall Jensen
- Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA
-
- Paul Keim
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- David M. Engelthaler
- Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA
-
- Peter Palese
- editor
この論文をさがす
説明
<jats:p>Enteroviruses frequently result in respiratory and gastrointestinal illness; however, multiple subtypes, including poliovirus, can cause severe neurologic disease. Recent biennial increases (i.e., 2014, 2016, and 2018) in cases of non-polio acute flaccid paralysis have led to speculations that other enteroviruses, specifically enterovirus D68 (EV-D68), are emerging to fill the niche that was left from poliovirus eradication. A cluster of 11 suspect cases of pediatric acute flaccid myelitis (AFM) was identified in 2016 in Phoenix, AZ. Multiple genomic analyses identified the presence of EV-D68 in the majority of clinical AFM cases. Beyond limited detection of herpesvirus, no other likely etiologies were found in the cluster. These findings strengthen the likelihood that EV-D68 is a cause of AFM and show that the rapid molecular assays developed for this study are useful for investigations of AFM and EV-D68.</jats:p>
収録刊行物
-
- mBio
-
mBio 10 (1), e02262-, 2019-02-26
American Society for Microbiology