The Distinct Immune-Stimulatory Capacities of Porphyromonas gingivalis Strains 381 and ATCC 33277 Are Determined by the <i>fimB</i> Allele and Gingipain Activity

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  • Stephen R. Coats
    Department of Periodontics, University of Washington, Seattle, Washington, USA
  • Nutthapong Kantrong
    Department of Periodontics, University of Washington, Seattle, Washington, USA
  • Thao T. To
    Department of Periodontics, University of Washington, Seattle, Washington, USA
  • Sumita Jain
    Department of Periodontics, University of Washington, Seattle, Washington, USA
  • Caroline A. Genco
    Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, USA
  • Jeffrey S. McLean
    Department of Periodontics, University of Washington, Seattle, Washington, USA
  • Richard P. Darveau
    Department of Periodontics, University of Washington, Seattle, Washington, USA
  • Marvin Whiteley
    editor

Abstract

<jats:p> The <jats:named-content content-type="genus-species">Porphyromonas gingivalis</jats:named-content> strain ATCC 33277 (33277) and 381 genomes are nearly identical. However, strain 33277 displays a significantly diminished capacity to stimulate host cell Toll-like receptor 2 (TLR2)-dependent signaling and interleukin-1β (IL-1β) production relative to 381, suggesting that there are strain-specific differences in one or more bacterial immune-modulatory factors. </jats:p>

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