The Distinct Immune-Stimulatory Capacities of Porphyromonas gingivalis Strains 381 and ATCC 33277 Are Determined by the <i>fimB</i> Allele and Gingipain Activity
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- Stephen R. Coats
- Department of Periodontics, University of Washington, Seattle, Washington, USA
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- Nutthapong Kantrong
- Department of Periodontics, University of Washington, Seattle, Washington, USA
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- Thao T. To
- Department of Periodontics, University of Washington, Seattle, Washington, USA
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- Sumita Jain
- Department of Periodontics, University of Washington, Seattle, Washington, USA
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- Caroline A. Genco
- Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts, USA
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- Jeffrey S. McLean
- Department of Periodontics, University of Washington, Seattle, Washington, USA
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- Richard P. Darveau
- Department of Periodontics, University of Washington, Seattle, Washington, USA
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- Marvin Whiteley
- editor
Abstract
<jats:p> The <jats:named-content content-type="genus-species">Porphyromonas gingivalis</jats:named-content> strain ATCC 33277 (33277) and 381 genomes are nearly identical. However, strain 33277 displays a significantly diminished capacity to stimulate host cell Toll-like receptor 2 (TLR2)-dependent signaling and interleukin-1β (IL-1β) production relative to 381, suggesting that there are strain-specific differences in one or more bacterial immune-modulatory factors. </jats:p>
Journal
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- Infection and Immunity
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Infection and Immunity 87 (12), 2019-12
American Society for Microbiology
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Details 詳細情報について
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- CRID
- 1363951794473165696
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- ISSN
- 10985522
- 00199567
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- Data Source
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- Crossref