Rat brains also have a default mode network

  • Hanbing Lu
    Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Programs, National Institutes of Health, Baltimore, MD 21224;
  • Qihong Zou
    Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Programs, National Institutes of Health, Baltimore, MD 21224;
  • Hong Gu
    Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Programs, National Institutes of Health, Baltimore, MD 21224;
  • Marcus E. Raichle
    Departments of Radiology, Neurology, Anatomy and Neurobiology, and Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110
  • Elliot A. Stein
    Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Programs, National Institutes of Health, Baltimore, MD 21224;
  • Yihong Yang
    Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Programs, National Institutes of Health, Baltimore, MD 21224;

書誌事項

公開日
2012-02-21
DOI
  • 10.1073/pnas.1200506109
公開者
Proceedings of the National Academy of Sciences

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説明

<jats:p>The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between rodent and primate brain, a well-organized, intrinsically coherent DMN appears to be a fundamental feature in the mammalian brain whose primary functions might be to integrate multimodal sensory and affective information to guide behavior in anticipation of changing environmental contingencies.</jats:p>

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