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- Ronald J. Hill
- CSIRO Animal, Food and Health Sciences, North Ryde, NSW 2113, Australia;
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- Isabelle M.L. Billas
- Department of Integrative Structural Biology, IGBMC, CNRS, UMR 7104, INSERM U964, Université de Strasbourg, Illkirch, 67404, France
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- François Bonneton
- Institut de Génomique Fonctionnelle de Lyon (IGFL), Université de Lyon, Université Lyon 1, CNRS, INRA, Ecole Normale Supérieure de Lyon, 69007 Lyon, France
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- Lloyd D. Graham
- CSIRO Animal, Food and Health Sciences, North Ryde, NSW 2113, Australia;
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- Michael C. Lawrence
- Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
説明
<jats:p> In 1974, Ashburner and colleagues postulated a model to explain the control of the puffing sequence on Drosophila polytene chromosomes initiated by the molting hormone 20-hydroxyecdysone. This model inspired a generation of molecular biologists to clone and characterize elements of the model, thereby providing insights into the control of gene networks by steroids, diatomic gases, and other small molecules. It led to the first cloning of the EcR subunit of the heterodimeric EcR-USP ecdysone receptor. X-ray diffraction studies of the ligand-binding domain of the receptor are elucidating the specificity of receptor-ecdysteroid interactions, the selectivity of some environmentally friendly insecticides, the evolution of the EcR-USP heterodimer, and indeed Ashburner's classical biochemical evidence for the central role of the ecdysone receptor in his model. </jats:p>
収録刊行物
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- Annual Review of Entomology
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Annual Review of Entomology 58 (1), 251-271, 2013-01-07
Annual Reviews
