Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

  • Robin N Beaumont
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • Nicole M Warrington
    Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, QLD, Australia,
  • Alana Cavadino
    Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK,
  • Jessica Tyrrell
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • Michael Nodzenski
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA,
  • Momoko Horikoshi
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK,
  • Frank Geller
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark,
  • Ronny Myhre
    Division of Epidemiology, Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway,
  • Rebecca C Richmond
    Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK,
  • Lavinia Paternoster
    Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK,
  • Jonathan P Bradfield
    Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA,
  • Eskil Kreiner-Møller
    Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark,
  • Ville Huikari
    Institute of Health Sciences, University of Oulu, Oulu, Finland,
  • Sarah Metrustry
    Department of Twin Research, King's College London, St. Thomas' Hospital, London, UK,
  • Kathryn L Lunetta
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA,
  • Jodie N Painter
    QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, QLD 4029, Australia,
  • Jouke-Jan Hottenga
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands,
  • Catherine Allard
    Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada,
  • Sheila J Barton
    Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK,
  • Ana Espinosa
    Pompeu Fabra University (UPF), Barcelona, Spain,
  • Julie A Marsh
    Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Australia,
  • Catherine Potter
    Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK,
  • Ge Zhang
    Human Genetics Division, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA,
  • Wei Ang
    Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Australia,
  • Diane J Berry
    Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK,
  • Luigi Bouchard
    Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada,
  • Shikta Das
    Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK,
  • Hakon Hakonarson
    Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA,
  • Jani Heikkinen
    FIMM Institute for Molecular Medicine Finland, Helsinki University, Helsinki FI-00014, Finland,
  • Øyvind Helgeland
    Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway,
  • Berthold Hocher
    The First Affiliated Hospital of Jinan University, Guangzhou 510630, China,
  • Albert Hofman
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands,
  • Hazel M Inskip
    Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK,
  • Samuel E Jones
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • Manolis Kogevinas
    Pompeu Fabra University (UPF), Barcelona, Spain,
  • Penelope A Lind
    QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, QLD 4029, Australia,
  • Letizia Marullo
    Genetic Section, Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy,
  • Sarah E Medland
    QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, QLD 4029, Australia,
  • Anna Murray
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • Jeffrey C Murray
    Department of Pediatrics, University of Iowa, Iowa City, IA, USA,
  • Pål R Njølstad
    Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway,
  • Ellen A Nohr
    Research Unit of Obstetrics & Gynecology, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark,
  • Christoph Reichetzeder
    Institute of Nutritional Science, University of Potsdam, Potsdam, Germany,
  • Susan M Ring
    Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK,
  • Katherine S Ruth
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • Loreto Santa-Marina
    ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain,
  • Denise M Scholtens
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA,
  • Sylvain Sebert
    Institute of Health Sciences, University of Oulu, Oulu, Finland,
  • Verena Sengpiel
    Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahgrenska University Hospital, Gothenburg, Sweden,
  • Marcus A Tuke
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • Marc Vaudel
    Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway,
  • Michael N Weedon
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • Gonneke Willemsen
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands,
  • Andrew R Wood
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • Hanieh Yaghootkar
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • Louis J Muglia
    Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, OH, USA,
  • Meike Bartels
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands,
  • Caroline L Relton
    Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK,
  • Craig E Pennell
    Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Australia,
  • Leda Chatzi
    Department of Social Medicine, University of Crete, Crete, Greece,
  • Xavier Estivill
    Pompeu Fabra University (UPF), Barcelona, Spain,
  • John W Holloway
    Human Development & Health, Faculty of Medicine, University of Southampton, Southampton, UK,
  • Dorret I Boomsma
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands,
  • Grant W Montgomery
    QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, QLD 4029, Australia,
  • Joanne M Murabito
    Framingham Heart Study, Framingham, MA, USA,
  • Tim D Spector
    Department of Twin Research, King's College London, St. Thomas' Hospital, London, UK,
  • Christine Power
    Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK,
  • Marjo-Ritta Järvelin
    Institute of Health Sciences, University of Oulu, Oulu, Finland,
  • Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark,
  • Struan F A Grant
    Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA,
  • Thorkild I A Sørensen
    Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK,
  • Vincent W Jaddoe
    The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands,
  • Bo Jacobsson
    Division of Epidemiology, Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway,
  • Mads Melbye
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark,
  • Mark I McCarthy
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK,
  • Andrew T Hattersley
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • M Geoffrey Hayes
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA,
  • Timothy M Frayling
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,
  • Marie-France Hivert
    Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA, USA,
  • Janine F Felix
    The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands,
  • Elina Hyppönen
    Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK,
  • William L Lowe
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA,
  • David M Evans
    Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, QLD, Australia,
  • Debbie A Lawlor
    Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK,
  • Bjarke Feenstra
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark,
  • Rachel M Freathy
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK,

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