Gut commensal <i>Lactobacillus reuteri</i> 100‐23 stimulates an immunoregulatory response

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  • Megan Livingston
    Department of Microbiology and Immunology, University of Otago Dunedin New Zealand
  • Diane Loach
    Department of Microbiology and Immunology, University of Otago Dunedin New Zealand
  • Michelle Wilson
    Department of Microbiology and Immunology, University of Otago Dunedin New Zealand
  • Gerald W Tannock
    Department of Microbiology and Immunology, University of Otago Dunedin New Zealand
  • Margaret Baird
    Department of Microbiology and Immunology, University of Otago Dunedin New Zealand

書誌事項

公開日
2009-09-29
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1038/icb.2009.71
公開者
Wiley

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説明

<jats:p><jats:italic>Lactobacillus reuteri</jats:italic> 100‐23 is a bacterial commensal of the gastrointestinal tract of mice. Previous studies have shown that colonization of the murine gut by this strain stimulates small‐bowel enterocytes to produce proinflammatory cytokines. This is associated with a mild, transitory inflammatory response 6 days after inoculation of formerly <jats:italic>Lactobacillus</jats:italic>‐free animals. The inflammation subsides by 21 days after colonization, although lactobacilli continue to be present in the bowel. To determine the immunological mechanisms that underpin tolerance to bowel commensals, we investigated cytokine responses of dendritic cells and T cells after exposure to cells of <jats:italic>L. reuteri</jats:italic> 100‐23. Interleukin‐10 (IL‐10), IL‐2 and transforming growth factor‐β (TGF‐β) concentrations in supernatants of cultured immune cells, as well as the results of proliferative assays of mesenteric lymph node (MLN) cells and quantification of Foxp3‐positive cells in MLN and spleen, indicated that <jats:italic>L. reuteri</jats:italic> 100‐23 stimulated the development of an increased number of regulatory T cells.</jats:p>

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