<i>N</i> -hydroxy-pipecolic acid is a mobile metabolite that induces systemic disease resistance in <i>Arabidopsis</i>

DOI Web Site 6 Citations
  • Yun-Chu Chen
    Department of Biology, Stanford University, Stanford, CA 94305-5020;
  • Eric C. Holmes
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305-5020;
  • Jakub Rajniak
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305-5020;
  • Jung-Gun Kim
    Department of Biology, Stanford University, Stanford, CA 94305-5020;
  • Sandy Tang
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305-5020;
  • Curt R. Fischer
    Chemistry, Engineering & Medicine for Human Health, Stanford University, Stanford, CA 94305-5020
  • Mary Beth Mudgett
    Department of Biology, Stanford University, Stanford, CA 94305-5020;
  • Elizabeth S. Sattely
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305-5020;

Description

<jats:title>Significance</jats:title> <jats:p> Plants lack circulating immune cells and instead rely on small molecule chemistry for local and long-distance defense signaling. Following pathogen attack, plants activate innate immune pathways at the site of infection to limit pathogen growth. Plants also possess the ability to prime similar immune responses in uninfected tissues to prevent the spread of pathogens or protect against new infections. Despite the importance of systemic immunity, the mechanism for signaling is not clear. In this study, we show that <jats:italic>N</jats:italic> -hydroxy-pipecolic acid metabolites are mobile defense signals produced at the site of bacterial infection and establish and amplify defense in uninfected, distal tissues. Our study illuminates the chemical nature of a mobile bioactive metabolite that confers pathogen resistance throughout the plant. </jats:p>

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