Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography

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  • Chunhui Li
    Department of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, WA 98195, USA
  • Guangying Guan
    Department of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, WA 98195, USA
  • Roberto Reif
    Department of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, WA 98195, USA
  • Zhihong Huang
    Division of Mechanical Engineering and Mechatronics, University of Dundee, Dundee, Angus DD1 4HN, UK
  • Ruikang K. Wang
    Department of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, WA 98195, USA

抄録

<jats:p> The mechanical properties of skin are important tissue parameters that are useful for understanding skin patho-physiology, which can aid disease diagnosis and treatment. This paper presents an innovative method that employs phase-sensitive spectral-domain optical coherence tomography (PhS-OCT) to characterize the biomechanical properties of skin by measuring surface waves induced by short impulses from a home-made shaker. Experiments are carried out on single and double-layer agar–agar phantoms, of different concentrations and thickness, and on <jats:italic>in vivo</jats:italic> human skin, at the forearm and the palm. For each experiment, the surface wave phase-velocity dispersion curves were calculated, from which the elasticity of each layer of the sample was determined. It is demonstrated that the experimental results agree well with previous work. This study provides a novel combination of PhS-OCT technology with a simple and an inexpensive mechanical impulse surface wave stimulation that can be used to non-invasively evaluate the mechanical properties of skin <jats:italic>in vivo</jats:italic> , and may offer potential use in clinical situations. </jats:p>

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