4‐(Dimethylamino)pyridine <i>N</i>‐oxide (DMAPO): An Effective Nucleophilic Catalyst in the Peptide Coupling Reaction with 2‐Methyl‐6‐nitrobenzoic Anhydride
書誌事項
- 公開日
- 2008-01-29
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/asia.200700305
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Various carboxamides or peptides were synthesized from the corresponding carboxylic acids and amines or α‐amino acids in high yields by the catalysis of 4‐(dimethylamino)pyridine <jats:italic>N</jats:italic>‐oxide (DMAPO) with 2‐methyl‐6‐nitrobenzoic anhydride (MNBA). Because the segment‐coupling reaction of α‐amino acids proceeds through the effective activation of the carboxylic acid moieties with DMAPO in the presence of tertiary amines under mild conditions, undesired racemization was hardly observed in the synthesis of oligopeptides such as Z‐Gly‐Phe‐Val‐OMe, Z‐Phe‐Val‐Ala‐OMe, and Bz‐Val‐Val‐OMe.</jats:p>
収録刊行物
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- Chemistry – An Asian Journal
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Chemistry – An Asian Journal 3 (2), 454-461, 2008-01-29
Wiley
