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- Rajal B. Shah
- 1Pathology, Departments of
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- Rohit Mehra
- 1Pathology, Departments of
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- Arul M. Chinnaiyan
- 1Pathology, Departments of
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- Ronglai Shen
- 4Biostatistics, University of Michigan School of Medicine, Ann Arbor, Michigan;
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- Debashis Ghosh
- 4Biostatistics, University of Michigan School of Medicine, Ann Arbor, Michigan;
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- Ming Zhou
- 1Pathology, Departments of
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- Gary R. MacVicar
- 2Medical Oncology,
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- Soorynarayana Varambally
- 1Pathology, Departments of
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- Jason Harwood
- 1Pathology, Departments of
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- Tarek A. Bismar
- 5Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts;
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- Robert Kim
- 5Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts;
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- Mark A. Rubin
- 5Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts;
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- Kenneth J. Pienta
- 2Medical Oncology,
抄録
<jats:title>Abstract</jats:title> <jats:p>Understanding the biology of prostate cancer metastasis has been limited by the lack of tissue for study. We studied the clinical data, distribution of prostate cancer involvement, morphology, immunophenotypes, and gene expression from 30 rapid autopsies of men who died of hormone-refractory prostate cancer. A tissue microarray was constructed and quantitatively evaluated for expression of prostate-specific antigen, androgen receptor, chromogranin, synaptophysin, MIB-1, and α-methylacylCoA-racemase markers. Hierarchical clustering of 16 rapid autopsy tumor samples was performed to evaluate the cDNA expression pattern associated with the morphology. Comparisons were made between patients as well as within the same patient. Metastatic hormone-refractory prostate cancer has a heterogeneous morphology, immunophenotype, and genotype, demonstrating that “metastatic disease” is a group of diseases even within the same patient. An appreciation of this heterogeneity is critical to evaluating diagnostic and prognostic biomarkers as well as to designing therapeutic targets for advanced disease.</jats:p>
収録刊行物
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- Cancer Research
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Cancer Research 64 (24), 9209-9216, 2004-12-15
American Association for Cancer Research (AACR)