Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development

DOI Web Site 被引用文献10件

書誌事項

公開日
2000-08-15
DOI
  • 10.1101/gad.14.16.2072
公開者
Cold Spring Harbor Laboratory

この論文をさがす

説明

<jats:p>Gastrulation in mice is associated with the start of extreme proliferation and differentiation. The potential cost to the embryo of a very rapid proliferation rate is a high production of damaged cells. We demonstrate a novel surveillance mechanism for the elimination of cells damaged by ionizing radiation during mouse gastrulation. During this restricted developmental window, the embryo becomes hypersensitive to DNA damage induced by low dose irradiation (<0.5 Gy) and undergoes apoptosis without cell cycle arrest. Intriguingly, embryonic cells, including germ cell progenitors, but not extraembryonic cells, become hypersensitive to genotoxic stress and undergo Atm- and p53-dependent apoptosis. Thus, hypersensitivity to apoptosis in the early mouse embryo is a cell fate-dependent mechanism to ensure genomic integrity during a period of extreme proliferation and differentiation.</jats:p>

収録刊行物

  • Genes & Development

    Genes & Development 14 (16), 2072-2084, 2000-08-15

    Cold Spring Harbor Laboratory

被引用文献 (10)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ