Application of the nucleophilic substitution reaction to the synthesis of No‐carrier‐added [<sup>18</sup>F]fluorobenzene and other <sup>18</sup>F‐labeled aryl fluorides

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<jats:title>Abstract</jats:title><jats:p>No‐carrier‐added (NCA) [<jats:sup>18</jats:sup>F]fluorobenzene was prepared in a multistep synthesis with a radiochemical yield of 20‐30%.</jats:p><jats:p>A series of NCA and CA <jats:sup>18</jats:sup>F‐labeled aryl fluorides which are important precursors of <jats:sup>18</jats:sup>F‐labeled butyrophenone neuroleptics have also been synthesized in radiochemical yields of 30–50%. The direct synthesis of [<jats:sup>18</jats:sup>F]spiroperidol and [<jats:sup>18</jats:sup>F]benperidol from the parent compounds and/or nitro and/or chloro compound using the nucleophilic substitution reactions were also investigated.</jats:p>

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