Buccal epithelium Expanded and Encapsulated in Scaffold‐Hybrid Approach to Urethral Stricture (BEES‐HAUS) procedure: A novel cell therapy‐based pilot study

DOI Web Site Web Site Web Site 被引用文献2件
  • Surya P Vaddi
    Department of Urology and Renal Transplantation Narayana Medical College Hospital Nellore Andhra Pradesh India
  • Vijaya B Reddy
    Department of Urology and Renal Transplantation Narayana Medical College Hospital Nellore Andhra Pradesh India
  • Samuel JK Abraham
    The Mary‐Yoshio Translational Hexagon Nichi‐In Center for Regenerative Medicine Chennai Tamil Nadu India

抄録

<jats:sec><jats:title>Objectives</jats:title><jats:p>To describe the feasibility of a novel cell‐based endoscopic technique using buccal epithelium, expanded and encapsulated in a thermoreversible gelation polymer scaffold for the treatment of urethral stricture.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Six male patients with bulbar urethral stricture ranging from 2.0 to 3.5 cm in length were included in this pilot study. Autologous buccal epithelial cells from a small buccal mucosal biopsy were isolated, cultured and encapsulated in thermoreversible gelation polymer scaffold, and were implanted at the stricture site after a wide endoscopic urethrotomy.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>All the patients voided well, with a mean peak flow rate of 24 mL/s. Urethroscopy carried out at 6 months showed healthy mucosa at the urethrotomy site. However, two of the six patients had recurrence at 18 and 24 months, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This endoscopic‐based Buccal epithelium Expanded and Encapsulated in Scaffold‐Hybrid Approach to Urethral Stricture (BEES‐HAUS) technique is a promising alternative for the open substitution buccal graft urethroplasty. It is possible to achieve the benefits of open substitution buccal urethroplasty with this endoscopic technique.</jats:p></jats:sec>

収録刊行物

被引用文献 (2)*注記

もっと見る

キーワード

問題の指摘

ページトップへ