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- Uku Vainik
- Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;
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- Travis E. Baker
- Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;
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- Mahsa Dadar
- Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;
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- Yashar Zeighami
- Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;
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- Andréanne Michaud
- Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;
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- Yu Zhang
- Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;
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- José C. García Alanis
- Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;
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- Bratislav Misic
- Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;
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- D. Louis Collins
- Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;
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- Alain Dagher
- Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada;
説明
<jats:title>Significance</jats:title> <jats:p>Obesity is a widespread heritable health condition. Evidence from psychology, cognitive neuroscience, and genetics has proposed links between obesity and the brain. The current study tested whether the heritable variance in body mass index (BMI) is explained by brain and behavioral factors in a large brain imaging cohort that included multiple related individuals. We found that the heritable variance in BMI had genetic correlations 0.25–0.45 with cognitive tests, cortical thickness, and regional brain volume. In particular, BMI was associated with frontal lobe asymmetry and differences in temporal-parietal perceptual systems. Further, we found genetic overlap between certain brain and behavioral factors. In summary, the genetic vulnerability to BMI is expressed in the brain. This may inform intervention strategies.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 115 (37), 9312-9317, 2018-08-28
Proceedings of the National Academy of Sciences