EFFECT OF OESTRADIOL-17β ON CLEAVAGE, NUCLEIC ACID METABOLISM AND PROTEIN SYNTHESIS IN SEA URCHIN, STRONGYLOCENTROTUS PURPURATUS, EMBRYOS
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<jats:title>SUMMARY</jats:title> <jats:p>Oestradiol-17β at a concentration of 3 × 10<jats:sup>−3</jats:sup> <jats:sc>m</jats:sc> inhibits cleavage in sea urchin (<jats:italic>Strongylocentrotus purpuratus</jats:italic>) embryos. This inhibition is accompanied by a reduction in deoxyribonucleic acid (DNA) synthesis and little change in ribonucleic acid (RNA).</jats:p> <jats:p>The effects of oestradiol-17β upon the incorporation of glycine-1-<jats:sup>14</jats:sup>C and glycine-2-<jats:sup>14</jats:sup>C into the purines of DNA and RNA and the incorporation of glycine-2-<jats:sup>14</jats:sup>C into serine were studied. The incorporation of glycine-1-<jats:sup>14</jats:sup>C and glycine-2-<jats:sup>14</jats:sup>C into RNA was reduced, but the incorporation of glycine-2-<jats:sup>14</jats:sup>C into DNA was increased considerably over that of the controls. The incorporation of glycine-2-<jats:sup>14</jats:sup>C into serine was also accelerated by oestradiol. A possible explanation of the action of oestradiol-17β is offered.</jats:p> <jats:p>The moderate effect upon RNA is not surprising because there is little or no synthesis of this compound from the time of fertilization to blastulation under normal conditions.</jats:p>
収録刊行物
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- Journal of Endocrinology
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Journal of Endocrinology 25 (2), 183-NP, 1962-10
Bioscientifica