Characterization of amphioxus <i>amphivent</i>, an evolutionarily conserved marker for chordate ventral mesoderm
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<jats:title>Abstract</jats:title><jats:p>Summary: Structure and developmental expression are described for amphioxus <jats:italic>AmphiVent,</jats:italic> a homolog of vertebrate <jats:italic>Vent</jats:italic> genes. In amphioxus, <jats:italic>AmphiVent</jats:italic>‐expressing ventral mesoderm arises at midneurula by outgrowth from the paraxial mesoderm, but in vertebrates, <jats:italic>Vent</jats:italic>‐expressing ventral mesoderm originates earlier, at the gastrula stage. In other embryonic tissues (nascent paraxial mesoderm, neural plate, endoderm, and tailbud), <jats:italic>AmphiVent</jats:italic> and its vertebrate homologs are expressed in similar spatiotemporal domains, indicating conservation of many <jats:italic>Vent</jats:italic> gene functions during chordate evolution. The ventral mesoderm evidently develops precociously in vertebrates because their relatively large embryos probably require an early and extensive deployment of the mesoderm‐derived circulatory system. The vertebrate ventral mesoderm, in spite of its strikingly early advent, still resembles the nascent ventral mesoderm of amphioxus in expressing <jats:italic>Vent</jats:italic> homologs. This coincidence may indicate that <jats:italic>Vent</jats:italic> homologs in vertebrates and amphioxus play comparable roles in ventral mesoderm specification. genesis 29:172–179, 2001. © 2001 Wiley‐Liss, Inc.</jats:p>
収録刊行物
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- genesis
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genesis 29 (4), 172-179, 2001-04
Wiley