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説明
<jats:p>This Account summarizes our involvement in the development of dearomatization reactions of indoles that has for origin a total synthesis problematic. We present the effort from our group to obtain 3D-indolines scaffold from the umpolung of N-acyl indoles via activation with FeCl3 to the oxidative spirocyclizations of N-EWG indoles and via the use of electrochemistry.</jats:p><jats:p>1 Introduction</jats:p><jats:p>2 Activation of N-Acyl Indoles with FeCl3 </jats:p><jats:p>2.1 Hydroarylation of N-Acyl Indoles</jats:p><jats:p>2.2 Difunctionalization of N-Acyl Indoles</jats:p><jats:p>3 Radical-Mediated Dearomatization of Indoles for the Synthesis of Spirocyclic Indolines</jats:p><jats:p>4 Electrochemical Dearomatization of Indoles</jats:p><jats:p>4.1 Direct Electrochemical Oxidation of Indoles</jats:p><jats:p>4.2 Indirect Electrochemical Oxidation of Indoles</jats:p><jats:p>5 Conclusion</jats:p>
収録刊行物
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- Synlett
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Synlett 31 (18), 1775-1788, 2020-06-24
Georg Thieme Verlag KG