The imitation game: a viral strategy to subvert the complement system

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  • Palak Agrawal
    Complement Biology Laboratory National Centre for Cell Science S. P. Pune University Campus Ganeshkhind Pune 411007 India
  • Samriddhi Sharma
    Complement Biology Laboratory National Centre for Cell Science S. P. Pune University Campus Ganeshkhind Pune 411007 India
  • Pradipta Pal
    Complement Biology Laboratory National Centre for Cell Science S. P. Pune University Campus Ganeshkhind Pune 411007 India
  • Hina Ojha
    Complement Biology Laboratory National Centre for Cell Science S. P. Pune University Campus Ganeshkhind Pune 411007 India
  • Jayati Mullick
    Microbial Containment Complex ICMR‐National Institute of Virology Pune 411021 India
  • Arvind Sahu
    Complement Biology Laboratory National Centre for Cell Science S. P. Pune University Campus Ganeshkhind Pune 411007 India

Abstract

<jats:p>Viruses are obligate parasites of cellular hosts and therefore are constantly confronted with the host immune system. Evasion of innate immunity mechanisms by viruses is paramount for the establishment of their infection. The complement system can directly neutralize viruses and also augments adaptive immune responses against them. This system, therefore, is central to host innate immune surveillance, and viruses have evolved a multitude of ways to escape its assault. A major strategy employed by viruses is the molecular mimicry of human complement regulators, namely regulators of complement activation (RCA) proteins and CD59. Herein, we outline up‐to‐date information on the structure, function and role of viral homologs of the human complement regulators in viral pathogenesis.</jats:p>

Journal

  • FEBS Letters

    FEBS Letters 594 (16), 2518-2542, 2020-06-23

    Wiley

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